Brassica oleracea commonly called as cabbage is a good vegetative source. It has been reported to have high antioxidant properties due to the presence various phytoconstituents. Extraction procedure was done by maceration process using aqueous methanol (20:80) as solvent and acute toxicity studies, phytochemical screening were carried out using standard procedures. In vitro antioxidant studies were conducted using DPPH method. For the present study, reserpine model was selected for parkinsonian disease. Reserpine is administered at a dose of 5mg/kg i.p., for 5 consecutive days. Behavioral parameters, biochemical parameters and histopathological changes were estimated. The groups treated with hydroalcoholic extract of Brassica oleracea (250 & 500mg/kg p.o.,) showed increased locomotor activity, motor coordination, SOD, CAT, GSH levels were as the cataleptic behavior and LPO was decreased when compared to negative control group. Histopathology also showed normal cerebellum. The pharmacological screening revealed that the plant extract shown dose dependent action. These results suggest the involvement of antioxidant activity in treating reserpine induced parkinsonian disease. It also confirms that the hydroalcoholic extract of Brassica oleracea (HABO) is having antioxidant activity which may be due to the presence of phytoconstituents like flavonoids. This study predicts the scope of Brassica oleracea in the possible treatment of neuroleptic-induced Parkinsonian Disease.
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